Interventions of Interest:

  • tirzepatide (Eli Lilly)

More than 34 million Americans, or 10% of the US population, have diabetes mellitus. Type 2 diabetes mellitus (T2DM), which is characterized by progressive loss of adequate insulin secretion from the pancreas and peripheral resistance to insulin, accounts for 90-95% of those cases. Prevalence of T2DM increases with age and minorities bear a disproportionate burden of disease, with American Indian/Alaska Natives, Blacks, Asians, and Hispanics at greater risk of developing or having diabetes, as well as developing complications from the disease. Obesity is a major risk factor for developing T2DM with more than 60% of people with diabetes having a body mass index (BMI) in the obese or extreme obesity range.

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