Topic: High Cholesterol

High Cholesterol

Feb 2021 | Assessment

Interventions of interest: inclisiran (Leqvio®, Novartis) bempedoic acid (Nexletol®, Esperion Therapeutics) bempedoic acid/ezetimibe (Nexlizet™, Esperion Therapeutics) An independent appraisal committee voted that the evidence is not adequate to demonstrate a net health benefit of bempedoic acid over usual care for the entire population of eligible patients, but is adequate when focused on patients unable to […]

High Cholesterol: PCSK9s

Feb 2019 | Assessment

Interventions of Interest: alirocumab (Praluent®, Regeneron/Sanofi) evolocumab (Repatha®, Amgen) Cardiovascular disease (CVD) is the most common cause of death in the United States and approximately one third of American adults have CVD. Low density lipoprotein cholesterol (LDL) is a major modifiable risk factor for myocardial infarction, stroke, and death from cardiovascular disease. The use of […]