Interventions of Interest:

  • Xanomeline tartrate/trospium chloride (KarXT, Karuna Therapeutics)

Schizophrenia is a serious mental illness that affects how a person thinks, feels, and behaves. The symptoms are typically separated into three general categories: positive (delusions, hallucinations, disorganized speech, thought and behavior); negative (poor motivation, lack of pleasure and enjoyment, lack of speech, lack of social interaction), and cognitive (impaired executive function, attention, and memory). These symptoms can negatively impact everyday functioning (e.g., attending work or school, socializing, personal care, etc.). The underlying cause of schizophrenia is unknown. It typically presents in adolescence or young adulthood and continues through the individual’s entire life.

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