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Explore Our Research / Assessments / Smoking Cessation

Smoking Cessation

An assessment of cytisinicline

Public Meeting
January 2026

Assessment Status

Closed

Public Comments

Closed

  • Overview
  • Full Timeline & Materials
  • Related Assessments & Articles

Intervention of Interest

  • cytisinicline (Achieve Life Sciences, Inc.)

For questions please contact [email protected].

View the Key Stakeholder List.

Final Documents

Final Evidence Report & Meeting SummaryDownload
Report-at-a-GlanceDownload
Final Policy RecommendationsDownload
The ICER Snapshot: for PatientsDownload
Draft Evidence ReportDownload
Response to Public CommentsDownload

Main Review
January 15, 2026

Midwest CEPAC

The Midwest CEPAC’s 2025 public meeting on cytisinicline

  • Evidence Presentation
  • Public Comment
  • Voting Questions
  • Policy Roundtable
Smoking Cessation Meeting Agenda

Related Assessments & Policy Papers.

Woman_in_passing

Special Assessment to Inform CMS Drug Price Negotiation: Breo Ellipta and Trelegy Ellipta

 Mar 2025

Chronic Obstructive Pulmonary Disease

 Jun 2024

Non-Small Cell Lung Cancer

 Oct 2016
05/20/2025

Draft Scoping Document

Download PDF

05/20/2025 - 06/10/2025

Public Comments on Draft Scoping Document

Download PDF

06/30/2025

Revised Scoping Document

Download PDF

07/09/2025

Research Protocol

Please find the research protocol here: https://osf.io/dhg5p

08/21/2025

Model Analysis Plan

Please find the model analysis plan here: https://osf.io/ruf7w

10/20/2025

Draft Evidence Report

Having trouble viewing the report? Click here. 

 

Download PDF

Draft Voting Questions

10/20/2025 - 11/17/2025

Public Comments on Draft Evidence Report

Download PDF

12/11/2025

Evidence Report

Download PDF

Revised Voting Questions

Response to Public Comments

01/15/2026

Evidence Presentation

Download PDF

02/12/2026

Final Evidence Report and Meeting Summary

Download PDF

Report-at-a-Glance

Final Policy Recommendations

The ICER Snapshot: for Patients

Related Assessments & Policy Papers

Special Assessment to Inform CMS Drug Price Negotiation: Breo Ellipta and Trelegy Ellipta

 Mar 2025

Chronic Obstructive Pulmonary Disease

 Jun 2024 Midwest CEPAC

Non-Small Cell Lung Cancer

 Oct 2016

Related Press Releases

Institute for Clinical and Economic Review Publishes Final Evidence Report on Medication for Smoking Cessation

Independent appraisal committee votes reflect a net health benefit for cytisinicline alone, but uncertainty when compared to varenicline; manufacturer setting a price for cytisinicline to align with value would help ensure public health goals for smoking cessation are met.

Read More 02/12/2026

Institute for Clinical and Economic Review Publishes Evidence Report on Medication for Smoking Cessation

Cytisinicline is effective for smoking cessation; a 12-week course of cytisinicline would be cost-effective if priced between $1,700 and $2,400.

Read More 12/11/2025

Institute for Clinical and Economic Review Releases Draft Evidence Report on Treatment for Smoking Cessation

Public comment period now open until November 17, 2025; Requests to make oral comment during public meeting also being accepted.

Read More 10/20/2025

Institute for Clinical and Economic Review to Assess Treatment for Smoking Cessation

Report will be subject of Midwest CEPAC meeting in January 2026; Draft Scoping Document open to public comment until June 10, 2025.

Read More 05/20/2025
Go to Press Releases

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