Intervontions of Interest:

  • fezolinetant (Astellas Pharma Inc.)

Eighty percent of women undergoing menopause experience vasomotor symptoms (VMS). VMS, characterized by hot flashes and night sweats, are thought to be brought on by decreased estrogen levels and increased neurokinin B (NKB) activity acting on the hypothalamus, which regulates body temperature. The change in hypothalamic thermoregulation increases blood flow to the skin, resulting in the VMS. Hot flashes typically develop as a sudden onset of heat in the upper chest and face which spreads throughout the body and that lasts two to four minutes. Hot flashes are often accompanied by profuse sweating and, when this occurs at night (night sweats), can cause sleep disruption. Additionally, the combination of vasodilation and sweating can rapidly lower body temperature and cause shivering.

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