Intervention of interest: Diabetes prevention programs The Centers for Disease Control and Prevention (CDC) estimates that 29.1 million Americans have diabetes and 1.7 million adults are newly diagnosed with diabetes mellitus each year. The direct medical costs of diabetes were estimated to be $176 billion in 2012. Interventions to prevent diabetes have the potential to save […]
Treatments of Interest: deflazacort (Emflaza®, PTC Therapeutics) eteplirsen (Exondys 51®, Sarepta) golodirsen (Vyondys 53®, Sarepta) Duchenne muscular dystrophy (DMD) is a genetically inherited neuromuscular disease that almost entirely affects boys and results in a progressive loss of muscle function, resulting in progressive weakness and eventual death usually from cardiac and respiratory failure. It is the […]
Interventions of Interest: elagolix (ORILISSA®, AbbVie) Endometriosis is a chronic gynecological condition with symptoms that include painful menstrual periods, nonmenstrual pelvic pain, and pain during intercourse, as well as infertility. Endometriosis affects between four and ten million women of reproductive age in the US. Because elagolix’s price aligns with clinical benefit only when compared to […]
Interventions of interest: Simeprevir (Olysio®, Janssen Products, LP) + sofosbuvir (Sovaldi®, Gilead Sciences, Inc.) Ledipasvir/sofosbuvir (Harvoni®, Gilead Sciences, Inc.) Daclatasvir (Daklinza™, Bristol-Myers Squibb Company) + sofosbuvir (Sovaldi®, Gilead Sciences, Inc.) Paritaprevir/ritonavir/ombitasvir + dasabuvir with ribavirin (Viekira Pak™, AbbVie, Inc.) Simeprevir (Olysio®, Janssen Products, LP)+ pegylated interferon and ribavirin Sofosbuvir (Sovaldi®, Gilead Sciences, Inc.) + ribavirin […]
Interventions of interest: Sofosbuvir (Sovaldi®, Gilead Sciences, Inc.)Simeprevir (Olysio®, Janssen Products, LP) Chronic hepatitis C is a common infection that is a major cause of chronic liver disease, liver failure, and hepatocellular carcinoma (HCC), and it is the leading indication for liver transplantation in the Western world. Prior to 2011, the combination of pegylated interferon […]
Interventions of Interest: tisagenlecleucel (KymriahTM , Novartis) axicabtagene ciloleucel (YescartaTM, Kite Pharma) ICER developed a report on chimeric antigen receptor t-cell (CAR-T) therapies for treatment of B-cell malignancies. The policy recommendations highlight that even though the pricing of current CAR-T therapies aligns with patient benefit there will be changes needed in future pricing, payment, and […]
Interventions of Interest: Acupuncture Cognitive behavioral therapy Mindfulness Yoga Tai Chi ICER developed a report assessing the comparative clinical effectiveness and value of certain non-pharmacologic, non-invasive interventions for chronic low back and neck pain. The report was the subject of a October 19, 2017 meeting of the California Technology Assessment Forum. Evidence from the report […]
Interventions of interest: Erenumab (Aimovig®, Amgen/Novartis) Fremanezumab (Ajovy®, Teva) Galcanezumab (Emgality®, Eli Lilly) Migraine is a common, recurrent headache disorder and is among the top ten causes of years lived with disability in the US. Someone experiencing a migraine episode may feel moderate-to-severe pain and other symptoms (e.g., nausea, vomiting, or sensitivity to light or […]
Interventions of interest, July 2014 review: OnabotulinumtoxinA (Botox®, Allergan, Inc) Transcutaneous electrical nerve stimulation (Cefaly®, Cefaly Technology) Single pulse transcranial magnetic stimulation (SpringTMS™, eNeura Inc.) Migraine is a common, recurrent headache disorder and is among the top ten causes of years lived with disability in the US. Someone experiencing a migraine episode may feel moderate-to-severe […]
Interventions of Interest: Carfilzomib (Kyprolis®, Onyx) Daratumumab (Darzalex®, Janssen Bitoech) Elotuzumab (Empliciti®, Bristol MeyersSquibb) Ixazomib (Ninlaro®, Takeda) Panobinostat (Farydak®, Novartis Pharmaceuticals Corp.) Pomalidomide (Pomalyst®, Celgene) Multiple myeloma is a cancer of the blood in which the bone marrow produces a high number of cancerous plasma cells. The excessive growth of plasma cells can cause bone […]