Interventions of interest: Home sleep testing Polysomnography Continuous positive airway pressure (CPAP) Mandibular advancement devices (MADs) Surgical procedures Weight loss interventions Obstructive sleep apnea (OSA) is a chronic disorder, characterized by repetitive stops and starts in breathing during a night of sleep. As muscles in the throat relax, partial (hypopnea) or complete (apnea) blockage of […]
Interventions of Interest: Buprenorphine (Subutex®, Reckitt Benckiser Pharmaceuticals Inc. Buprenorphine and naloxone (Suboxone®, Indivior Inc.) Dose-tapering strategies for methadone or Suboxone, with or without naltrexone (Revia®, Duramed Pharmaceuticals, Inc. Naltrexone (Vivitrol®, Alkermes, Inc.) Use of naltrexone alone without prior stabilization on methadone or buprenorphine Drug-free opioid withdrawal management A 2014 review assessed MAT with methadone […]
Interventions of interest: Monthly buprenorphine injection (Sublocade™, Indivior) Buprenorphine implant (Probuphine®, Braeburn/Titan) Buprenorphine extended release injection (Sublocade®, Braeburn) These therapies were compared to MAT with methadone, buprenorphine/naloxone sublingual film (Suboxone®, Indivior), and injectable naltrexone (Vivitrol®, Alkermes). Opioid use disorder has reached a critical level in the United States, driven by over-prescription and diversion of opioid […]
ICER assessed the comparative clinical effectiveness and economic value of supervised injection facilities (SIFs). ICER has reviewed other related topics, such as abuse-deterrent opioid formulations, medication-assisted treatment for opioid use disorder, and non-drug interventions for lower back pain. This review reinforced ICER’s commitment to provide an independent evaluation of the evidence around interventions that target […]
Interventions of Interest: Abaloparatide (Tymlos®, Radius Health, Inc.) Teriparatide (Forteo®, Eli Lilly and Co.) Osteoporosis, the weakening of the bones through loss of bone mineral content and a decrease in bone quality, is a common disease of aging that affects approximately 10 million Americans. Approximately half of women and one quarter of men will suffer […]
Palliative care is a management approach that provides symptom relief and comfort care to patients with serious or life-threatening illnesses, with the goal of improving quality of life for both patients and their families. Unlike hospice care, which is typically restricted to individuals with a prognosis of survival of six months or less, palliative care can begin at […]
Treatments of Interest: peanut immunotherapy (Viaskin® Peanut, DBV Technologies) peanut immunotherapy (PalforziaTM, Aiummune) Peanut is a common childhood allergen in the United States (US). According to recent estimates approximately 1.4-4.5% of children suffer from peanut allergy. It is more common in males (1.7% versus 0.8%), people with lower income (1.7% versus 1.2%), and there are […]
Interventions of Interest: Intensity modulated radiation therapy for prostate cancer Prostate cancer is the most common nondermatologic cancer in men. In 2006, approximately230,000 new patients in the United States were diagnosed with prostate cancer and 27,000 men died of the disease. The major treatment options for localized prostate cancer include external beam radiation therapy, brachytherapy, […]
Interventions of Interest: Brachytherapy and Proton beam therapy for prostate cancer. Prostate cancer is the second leading cause of cancer deaths and the seventh overall causeof death in men in the United States (Centers for Disease Control and Prevention, 2008).Given that most new cases are diagnosed at an early, localized stage, significant attentionhas been focused […]
ICER developed a report on Active Surveillance and Radical Prostatectomy for prostate cancer. Prostate cancer is the second leading cause of cancer deaths and the seventh overall causeof death in men in the United States (Centers for Disease Control and Prevention, 2008).Given that most new cases are diagnosed at an early, localized stage, significant attentionhas […]