Intervention of Interest: Obeticholic Acid (OCALIVA®, Intercept Pharmaceuticals, Inc.) Obeticholic acid (OCA) is a novel bile acid analogue that has shown positive effects on biochemical markers of liver function in phase II trials and was approved by the FDA for treatment of primary biliary cholangitis (PBC) after failure of ursodeoxycholic Acid (UDCA). Primary biliary cholangitis (PBC), […]
ICER planned to assess the comparative clinical effectiveness and value of obeticholic acid (Intercept) for the treatment of non-alcoholic steatohepatitis (NASH). For questions, please contact info@icer.org. Update as of July 1, 2020: ICER will not hold the August 2020 Midwest CEPAC public meeting to discuss the comparative clinical effectiveness and value assessment of obeticholic acid […]
Interventions of Interest: Tyrosine kinase inhibitors: Afatinib (Gilotrif®, Boehringer Ingelheim Pharmaceuticals, Inc.) Erlotinib (Tarceva®, Genentech, Inc. and Astellas Pharma US, Inc.) Gefitinib (Iressa®, AstraZeneca) Immunotherapies targeting the programmed death 1 (PD-1) receptor or its ligand (PD-L1): Atezolizumab (Tecentriq®, Genentech, Inc., Roche Group) Nivolumab (Opdivo®, Bristol-Meyers Squibb Co.) Pembrolizumab (Keytruda®, Merck & Co.) Lung cancer is […]
Interventions of interest: Home sleep testing Polysomnography Continuous positive airway pressure (CPAP) Mandibular advancement devices (MADs) Surgical procedures Weight loss interventions Obstructive sleep apnea (OSA) is a chronic disorder, characterized by repetitive stops and starts in breathing during a night of sleep. As muscles in the throat relax, partial (hypopnea) or complete (apnea) blockage of […]
Interventions of Interest: Buprenorphine (Subutex®, Reckitt Benckiser Pharmaceuticals Inc. Buprenorphine and naloxone (Suboxone®, Indivior Inc.) Dose-tapering strategies for methadone or Suboxone, with or without naltrexone (Revia®, Duramed Pharmaceuticals, Inc. Naltrexone (Vivitrol®, Alkermes, Inc.) Use of naltrexone alone without prior stabilization on methadone or buprenorphine Drug-free opioid withdrawal management A 2014 review assessed MAT with methadone […]
Interventions of interest: Monthly buprenorphine injection (Sublocade™, Indivior) Buprenorphine implant (Probuphine®, Braeburn/Titan) Buprenorphine extended release injection (Sublocade®, Braeburn) These therapies were compared to MAT with methadone, buprenorphine/naloxone sublingual film (Suboxone®, Indivior), and injectable naltrexone (Vivitrol®, Alkermes). Opioid use disorder has reached a critical level in the United States, driven by over-prescription and diversion of opioid […]
ICER assessed the comparative clinical effectiveness and economic value of supervised injection facilities (SIFs). ICER has reviewed other related topics, such as abuse-deterrent opioid formulations, medication-assisted treatment for opioid use disorder, and non-drug interventions for lower back pain. This review reinforced ICER’s commitment to provide an independent evaluation of the evidence around interventions that target […]
Interventions of Interest: Abaloparatide (Tymlos®, Radius Health, Inc.) Teriparatide (Forteo®, Eli Lilly and Co.) Osteoporosis, the weakening of the bones through loss of bone mineral content and a decrease in bone quality, is a common disease of aging that affects approximately 10 million Americans. Approximately half of women and one quarter of men will suffer […]
Palliative care is a management approach that provides symptom relief and comfort care to patients with serious or life-threatening illnesses, with the goal of improving quality of life for both patients and their families. Unlike hospice care, which is typically restricted to individuals with a prognosis of survival of six months or less, palliative care can begin at […]
Treatments of Interest: peanut immunotherapy (Viaskin® Peanut, DBV Technologies) peanut immunotherapy (PalforziaTM, Aiummune) Peanut is a common childhood allergen in the United States (US). According to recent estimates approximately 1.4-4.5% of children suffer from peanut allergy. It is more common in males (1.7% versus 0.8%), people with lower income (1.7% versus 1.2%), and there are […]